I am providing you with 6 articles about the herb Tribulus terrestris, 2 full-texts providing fundamentals and 4 recent abstracts with interesting updates. 
We tend to use this herb to boost testosterone, and its reputation in Western world comes from athletes who benefit from its effects on the musculature. 
I was recently intrigued by reading criticisms about its efficacy for sports. Thus, I have decided to research the available evidence on PubMed databank. 
In fact, findings are very reassuring, and Tribulus terrestris properties go well beyond what I thought. Major Ayurvedic herbs are really worth exploring! 
I wish you fruitful reading and peaceful Sunday! 
2005.01 - A. Saponins in Tribulus terrestris – Chemistry and Bioactivity - FT edited.pdf
2014.12 - B. Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction - FT edited.pdf
2016.05 - C. Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM) - abstract edited.pdf
2016.06 - D. Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms - abstract edited.pdf
2017.06 - E. Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men - abstract edited.pdf
2018.05 - F. Efficacy of Tribulus Terrestris for the treatment of premenopausal women with hypoactive sexual desire disorder - A randomized double-blinded, placebo-controlled trial - abstract edited.pdf


I use loads of Calcium-D-Glucarate together with DIM to help my patients to detoxify œstradiol. 
DIM sends more œstradiol into the 2 hydroxylation pathway within phase I of liver detoxification. 
Calcium-D-glucarate inhibits gut bacterial beta-glucuronidase, thus fights œstradiol reabsorption. 
They work in close synergy.  However, there is more for you to learn about calcium-D-glucarate! 
Please read and enjoy the 5 attached articles, all duly highlighted to accelerate learning process. 
Have a nice Sunday! 
1990.10 - A. Potential use of D-glucaric acid derivatives in cancer prevention - abstract edited.pdf
2002.08 - B. Calcium-D-glucarate - FT edited.pdf
2007.01 - C. Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin - abstract edited.pdf
2008.09 - D. The biological role of D-glucaric acid and its derivatives - Potential use in medicine - FT edited.pdf
2011.01 - E. Dietary D-glucarate effects on the biomarkers of inflammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A:J mice - FT edited.pdf

4S41 - HMB

We cover an unusual topic today, i.e. beta-hydroxy-beta-methylbutyrate that we can comfortably call HMB. 
This has been a major player in sports medicine for many years as being ‘the’ effective lean mass booster. 
In fact, I only trust HMB and creatine as anti-catabolic agents.  They benefit from loads of reliable studies. 
A recent move consists in promoting HMB use to fight sarcopenia among the elderly sedentary population. 
I attach 6 articles, 2 full-text and 4 abstracts, all duly highlighted.  I insist about before-last one (May 2018). 
Don’t be fooled: there are more applications than you might think, such as boosting post-surgery recovery. 
Dosage appears pretty standard, i.e. 3 grams of HMB per day, which has been used in most of the studies. 
Please enjoy this new information and relax yourselves on your StudiouS Sunday! 
2015.07 - A. Usefulness of Β-hydroxy-Β-methylbutyrate (HMB) Supplementation in Different Sports - An Update and Practical Implications - FT edited.pdf
2015.09 - B. Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults - A systematic review and meta-analysis - abstract edited.pdf
2018.01 - C. Role of Oral Nutritional Supplements Enriched with β-Hydroxy-β-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings - FT edited.pdf
2018.04 - D. The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage - A Systematic Review and Meta-Analysis - abstract edited.pdf
2018.05 - E. Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations? - abstract edited.pdf
2018.07 - F. Pre-exercise β-hydroxy-β-methylbutyrate free-acid supplementation improves work capacity recovery - A randomized, double-blinded, placebo-controlled study - abstract edited.pdf


I personally prescribe loads of allicin to address intestinal dysbiosis, especially in case of IBS-C (constipation dominated irritable bowel). 
The reason is that allicin represents by far the best antimicrobial ever found - would it be natural or prescriptive - to tackle methanogens. 
These microbes, which are not bacteria but archaea, secrete methane, which is massively constipating.  It thus shows worth addressing! 
By reading these 6 full-text articles duly highlighted, you will find out the amazing properties of allicin which go way beyond antimicrobial. 
I know our nutritionist Linda is a big fan of allicin because of its large spectrum antimicrobial activity: yeast, bacteria, archaea, protozoan. 
Besides, allicin shows extremely safe and can be given to kids or during conception and pregnancy.  Nothing can show easier and safer! 
I wish you an excellent studious Sunday! 
2014.08 - A. Allicin Chemistry and Biological Properties - FT edited.pdf
2016.11 - B. Effects of Allicin on Hypertension and Cardiac Function in Chronic Kidney Disease - FT edited.pdf
2017.08 - C. Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia - FT edited.pdf
2017.09 - D. The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan - FT edited.pdf
2017.11 - E. Neuroprotective effects of allicin on ischemia-reperfusion brain injury - FT edited.pdf
2018.04 - F. Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer - FT edited.pdf


Quite unusually, today’s scientific evidence shall rely on one article only. 
This results from the topic being relatively controversial, i.e. reverse T3. 
I have fortunately spotted very recent and useful article about this topic. 
I hope you will find it a good read as it includes many thyroid reminders. 
My view is that it shall not prevent us from ‘carefully' testing reverse T3. 
You need making your own decisions, which is crucial medical principle. 
I wish you a great reading.  Enjoy a much shorter workload for this time! 
2018.06 - A. Reverse T3 or perverse T3? Still puzzling after 40 years - FT edited.pdf


Today, I provide you with 6 articles about alpha-lipoic acid, 3 full-texts and 3 abstracts, all duly highlighted for you. 
Don’t be fooled: this antioxidant is massive player to fight oxidative stress, prediabetes, and metabolic syndrome! 
It would be much more prescribed if it was not so expensive, especially the natural version called “R” enantiomer. 
But that's something we are solving thanks to accessing a cheap range of new high strength and quality products. 
In all cases, make sure you only prescribe the natural ‘R' version, never the synthetic mix of ‘R' & ‘L' enantiomers. 
I insist that you read these articles: how could we ignore such a powerful molecule dealing with insulin resistance! 
I wish you an excellent studious Sunday! 
2017.11 - A. Biochemical and clinical relevance of alpha lipoic acid - Antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential - FT edited.pdf
2018.06 - B. The Beneficial Effects of α-Lipoic Acid in Critically Ill Patients - A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial - abstract edited.pdf
2018.08 - C. A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy - abstract edited.pdf
2018.09 - D. Alpha-lipoic acid preserves skeletal muscle mass intype 2 diabetic OLETF rats - FT edited.pdf
2018.10 - E. The effects of alpha-lipoic acid supplementation onglucose control and lipid profiles among patients with metabolic diseases- A systematic review and meta-analysis of randomized controlled trials - FT edited.pdf
2018.11 - F. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level - abstract edited.pdf


Quercetin is without any doubt one of the most potent phytonutrients available to us thanks to extremely strong antioxidant activity. 
I have now decided to use it on its own, besides recommending through diet, especially from red onions, shallots, capers & lovage. 
It belongs to lists provided to our patients: Nrf2 and Sirtuin activators (essential for respectively NQO1 & OGG1 variant genotypes). 
It is also a major activator of AMPK (AMP-activated protein kinase), fundamental metabolic sensor connected to loads of pathways. 
In short, you can't skip it!  I'm providing here 5 full-text duly highlighted articles: basic facts (A-B) and cutting-edge updates (C-D-E). 
Please read and you will confirm that quercetin possesses some magic that many patients should benefit from - supplement or diet! 
I wish you an enjoyable “study” and a great Sunday! 
2016.07 - A. Overviews of Biological Importance of Quercetin - ABioactive Flavonoid - FT edited.pdf
2018.01 - B. Safety Aspects of the Use of Quercetin as a DietarySupplement - FT edited.pdf
2018.07 - C. Therapeutic potential of quercetin as a cardiovascular agent - FT edited.pdf
2018.07 - D. Anticancer potential of quercetin - A comprehensivereview - FT edited.pdf
2018.09 - E. Quercetin in Food - Possible Mechanisms of Its Effect on Memory - FT edited.pdf


Do you know about honokiol?  It is a major plant antioxidant that has been recently triggering increased interest for its multiple benefits. 
My research has started from its critical capacity to activate SIRT3, which comes into focus when one presents variant OGG1 genotype. 
I am presenting today 6 duly highlighted articles, 4 full-texts and two recent abstracts, among which D covers SIRT3 activating property. 
I let you discover the others, which bring a range of potential indications probably resulting from improved SIRT3, which is a BIG deal… 
I wish you another fruitful learning journey on a peaceful autumn Sunday! 
2006.06 - A. Overview of the Pharmacological Features of Honokiol - FT edited.pdf
2010.09 - B. Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders - FT edited.pdf
2012.12 - C. Honokiol - A novel natural agent for cancer prevention and therapy - FT edited.pdf
2015.04 - D. Honokiol blocks and reverses cardiac hypertrophy inmice by activating mitochondrial SIRT3 - FT edited.pdf
2017.11 - E. Neuroprotective effects of honokiol - From chemistry to medicine - abstract edited.pdf
2018.11 - F. Honokiol - An anticancer lignan - abstract edited.pdf


Today is the first of three “4S” emails (4S47-4S50-4S52) elaborated by Glenn MATTEN, our nutritionist! 
You will all be familiar with gamma-glutamyl transferase (GGT) in its traditional role as a marker of liver and bile duct conditions, and of course alcohol consumption. But did you know about the new understanding of GGT as a powerful predictive biomarker associated with a multitude of diseases encompassing cardiovascular disease, diabetes, metabolic syndrome, cancer and all-cause mortality? What is perhaps most startling about these findings is that the positive association between GGT and disease risk appears to be dose dependent across the normal lab reference range.
To understand these striking findings, we need to develop a new appreciation of GGT as a marker of oxidative stress. As you will see from the attached articles, it plays a fundamental role in glutathione metabolism and has an intricate inter-relationship with serum ferritin. Thus, measuring GGT, and viewing it in the context of serum ferritin, high sensitivity CRP, and glutathione, gives a potent insight into the fundamental cellular processes of oxidative stress, inflammation, and ultimately disease risk.
To give you a flavour of this new understanding of GGT, I attach a series of papers and abstracts. Intriguingly, we see that natural components of foods like coffee and turmeric appear to reduce GGT. Which gives rise to an intriguing hypothesis to explore: if GGT is fundamentally a marker of oxidative stress, could dietary activation of Nrf2 (refer back to the 4S4 topic on Nrf2 from January!) be an effective answer to dealing with patients with elevated GGT?
Thank you Glen!  Four articles he recommends you to read are attached hereunder.  Highlighting is mine. 
I wish you another fascinating journey into discovering new science altogether with an enjoyable Sunday! 
2000.05 - A. Coffee consumption and decreased serum gamma-glutamyltransferase a study of middle-aged Japanese men - abstract edited.pdf
2012.04 - B. Gamma-glutamyl transferase risk and prognosis of cancer - FT edited.pdf
2015.10 - C. Gamma-Glutamyltransferase A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk - FT edited.pdf
2018.01 - D. Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease - FT edited.pdf


Today, you are receiving a second round of scientific data that further validate my interpretation of apoE genotype. 
These are 4 of the most recent articles published on the topic, all highlighted full-texts, and they are worth reading. 
I strongly recommend extensively analyzing the latest article published in October 2018 by Cornell University team. 
Interestingly, it keeps open some level of controversy about the ideal dietary advice for E4 and for non-E4 carriers. 
New studies are on the way, which outcomes will be scrutinized and shared with you when they become available. 
I insist on additional preventive strategies, in particular benefits obtained with higher levels of DHA and vitamin D3. 
However, my short introduction’s goal is not to summarize the joined articles: I invite you to download and to read! 
Download, read, learn, reflect, and enjoy up-to-date science and knowledge!  I am sure that will make your Sunday. 
2000.05 - A. Coffee consumption and decreased serum gamma-glutamyltransferase a study of middle-aged Japanese men - abstract edited.pdf
2017.07 - N. ApoE Genotype Influences Insulin Resistance - FT edited.pdf
2017.12 - P. Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction - FT edited.pdf
2018.04 - V. Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors - FT edited.pdf
2018.10 - W. Clinical Application of APOE in Alzheimer's Prevention - A Precision Medicine Approach - FT edited.pdf

4S49 - LOW IGA

I struggle to understand how any Functional MD could meet any new patient without testing him or her for Immunoglobulins A (IgA). 
This marker shows as useful if showing “LOW” or “HIGH”.  Latter shows mucosal inflammation and even suggest autoimmune risks. 
Today is about “LOW” IgA, which is quite frequent, and not necessarily ‘suppressed' IgA, which rarely occurs and is more damaging. 
As you will find out through reading, low IgA increases the risk for: a) inflammation; b) allergies (and IgG sensitivity); c) autoimmunity. 
Patients with low IgA are much more at risk of suffering from relapsing intestinal dysbiosis and digestive issues, exactly as FUT2 AA. 
FUT2 AA means homozygous variant genotype, which implies these patients cannot secrete fucosyltransferase 2 or “non-secretors”. 
Non-secretor status is not good background for intestinal health, exactly as low IgA status.  If both happen simultaneously, it is tough. 
Majority of complex paediatric cases (e.g. bad digestion, allergies, severe skin issues, autoimmune attacks...) present both problems. 
I wish you another fruitful reading from these seven attached articles. 
And don’t forget, knowledge IS power!   :-)) 
2011.04 - A. Immunoglobulin responses at the mucosal interface -FT edited.pdf
2012.01 - B. The Microbiome in Infectious Disease and Inflammation - FT edited.pdf
2013.12 - C. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis - FT edited.pdf
2014.02 - D. IgA deficiency and autoimmunity - abstract edited.pdf
2015.09 - E. BALB-c and C57BL-6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity - FT edited.pdf
2015.11 - F. Autoimmunity and Immunodeficiency - abstract edited.pdf
2016.11 - G. The epithelial barrier and immunoglobulin A system in allergy - FT edited.pdf


We will enjoy Glen’s Christmas gift today and I can reassure you that we will receive a New Year gift as well in two weeks. 
I always noticed that coffee has always been one of his passions, likely because of the controversies and the antioxidants. 
Along the years, science has evolved about coffee's merits and side effects. We benefit here from a fully updated survey.
Let's deliver Glen’s introduction followed by 5 articles, i.e. 2 full-texts and 3 abstracts,which I have highlighted to help you.

"‭Speaking as a nutritionist (probably it is the same for Functional Medicine doctors…) I am aware that many patients are filled with trepidation that I will systematically forbid life’s pleasures one by one. Of course that is not the case, as is consummately illustrated with coffee. The list of coffee’s health benefits steadily expands, encompassing metabolic, cardiovascular, neurological, gastrointestinal and liver health. And should we be surprised when we consider it contains over 1,000 bioactive compounds and is a polyphenol-powerhouse?

And I must point out the inherent irony that coffee is one of the first things struck off when people embark on a so-called “detox” to give their liver a rest, when its benefits for liver health are unrivalled. So much so that one of the papers I attach for you is ‘Coffee: The magical bean for liver diseases”!

Of course, coffee will not be suitable for everyone given that caffeine sensitivity varies greatly (due to individual genomic settings typically affecting gene called CYP1A2 - GM) and caffeine must be restricted in a variety of situations such as pregnancy. However, the cheery news you can give your patients is that, unless there is a need to avoid or minimise it, they should go on enjoying their coffee in the knowledge it is good for them!"

Have a nice Sunday! 

2016.04 - A. Effects of coffee-caffeine on brain health and disease - What should I tell my patients - abstract edited.pdf
2017.05 - B. Coffee - The Magical Bean for Liver Diseases - FT edited.pdf
2017.11 - C. Coffee consumption and health - Umbrella review of meta-analyses of multiple health outcomes - FT edited.pdf
2018.05 - D. Coffee for cardioprotection and longevity - abstract edited.pdf
2018.06 - E. Coffee consumption and reduced risk of developing type 2 diabetes - A systematic review with meta-analysis - abstract edited.pdf

4S51 - LPS-BP

Today’s topic corresponds to a biological test that I now find very useful to run, LPS-BP or Lipopolysaccharide Binding Protein. 
Secretion of LPS-BP (by enterocytes and liver) represents our reaction to LPS (gram negative bacterial endotoxins) presence. 
It shows the existence of intestinal inflammation / dysbiosis strongly correlated with metabolic syndrome, obesity, sleep apnea. 
It is fascinating how the more we know about the intestinal ecosystem, the more we understand it directly impacts metabolism. 
That is exactly why most people get confused about calories, sweeteners, etc.  What really matters is how food affects the gut! 
I hope that you will enjoy exploring this revolutionary approach through six full-text articles (duly highlighted to hasten reading). 
I wish you a great Sunday that will be followed by festive week full of happiness before I send your last “4S” email (from Glen!).  
2012.05 - A. LPS-binding protein enables intestinal epithelialrestitution despite LPS exposure - FT edited.pdf
2013.01 - B. Determinants of Serum Concentrations of Lipopolysaccharide-Binding Protein (LBP) in the Adult Population - The Role of Obesity - FT edited.pdf
2013.02 - C. Porphyromonas gingivalis LPS stimulates the expression of LPS-binding protein in human oral keratinocytes in vitro - FT edited.pdf
2016.04 - D. Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm - Implications for a role of LBP in intracellular LPS-signaling - FT - edited.pdf
2018.05 - E. The level of lipopolysaccharide-binding protein is elevated in adult patients with obstructive sleep apnea - FT edited.pdf
2018.06 - F. Association of gut microbial communities with plasma lipopolysaccharide-binding protein (LBP) in premenopausal women - FT edited.pdf


Everything comes to an end and this last topic kindly managed by Glen (with his well acknowledged talent) concludes a series of 52 educative emails throughout the year 2018! 
He covers “resveratrol”, which I remind you should be highly recommended to OGG1 variant genotypes to boost companion gene SIRT3 as a compensation to poor DNA repair. 
it also appears that resveratrol, together with all sirtuin activators (see attached LIST), should be recommended to all patients presenting homozygous variant MAO-A genotype. 
I have come to learn that the molecules that plants produce in response to stress are amongst the most potent health promoting nutrients we can consume. The grandfather of them all is of course Resveratrol, a phytoalexin synthesised by plants in response to stress, injury, infection and UV radiation.
Its impressive pharmacological properties encompass antioxidant, anti-inflammatory and immuno-regulatory properties and its interaction with very potent biochemical targets including sirtuins, AMPK, Nrf2, NFkB, and numerous others, means that is has been investigated for its therapeutic benefits in a host of chronic disease states, which forms the topic of the extensive review in the first of the attached articles. With caloric restriction mimetic effects, resveratrol has also gained widespread attention as an antidote to the very ageing process itself, which forms the subject of the second paper, and highlights both the progress made in this field and the substantial challenges that remain. 
Resveratrol is available through food sources and at higher doses through supplementation (trans form being more potent than the cis form). So to help you see in the New Year, I have also attached a paper looking at the health benefits of its most famous dietary source: red wine. What better way to celebrate the arrival of 2019!
As usual, I have highlighted the articles except the third one. 
That's my way to protest about alcohol promotion: I disagree. 
But of course you can exceptionally drink red wine tomorrow. 
I wish you an exciting reading and an exciting New Year eve! 
2015.01 - A. Lifespan and healthspan extension by resveratrol - FT edited.pdf
2018.08 - B. Wine an aspiring agent in promoting longevity andpreventing chronic diseases - FT.pdf
2018.11 - C. Resveratrol from enhanced biosynthesis and bioavailability to multitargeting chronic diseases - FT edited.pdf
Cookies facilitate the provision of our services. By using our services, you agree that we use cookies.
More info